Background H19 and IGF2 genes are imprinted and involved in regulating fetal and
placental growth. The H19 differentially methylated region (DMR) is paternally methylated …

The PIK3CA‐related overgrowth spectrum (PROS) encompasses various conditions caused
by mosaic activating PIK3CA variants. PIK3CA somatic variants are also involved in various …

It has been postulated that imprinting aberrations are common in tumors. To understand the
role of imprinting in cancer, we have characterized copy-number and methylation in over …

Abstract Beckwith–Wiedemann spectrum, Simpson–Golabi–Behmel syndrome, familial
adenomatous polyposis and trisomy 18 are the most common congenital conditions …

Beckwith–Wiedemann syndrome (BWS) is the most common imprinting disorder and
consequently, one of the most common cancer predisposition disorders. Over the past 20 …

Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth
of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some …

Astroblastomas (ABs) are rare brain tumors of unknown origin. We performed an integrative
genetic and epigenetic analysis of AB-like tumors. Here, we show that tumors traceable to …

Abstract Beckwith‐Wiedemann Spectrum (BWSp) is an overgrowth and cancer
predisposition disorder characterized by a wide spectrum of phenotypic manifestations …

This article links the understanding of the developmental physiology of the adrenal cortex to
adrenocortical tumor formation. Many molecular mechanisms that lead to the formation of …

Abstract The prevalence of Beckwith–Wiedemann spectrum (BWSp) is tenfold increased in
children conceived through assisted reproductive techniques (ART). More than 90% of ART …