The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a
number of mechanical forces, including frictional shear flow, pulsatile stretching and …

Abstract In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (FBN1) mutations can
lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS …

Thoracic aortic aneurysm is characterized by dilation of the aortic diameter by greater than
50%, which can lead to dissection or rupture. Common histopathology includes extracellular …

To improve the current treatment for vascular diseases, such as vascular grafts, intravascular
stents, and balloon angioplasty intervention, the evaluation of the native blood vessel …

Marfan Syndrome (MFS), a connective tissue disorder caused by a mutation in the fibrillin-1
gene, occurs in approximately 1 in 5,000 people worldwide. As an important constituent of …

Introduction: Ascending aortic aneurysm is a serious health risk. In order to study ascending
aortic aneurysms, elastase and calcium ion treatment for aneurysm formation are mainly …

Atherosclerosis is a common cardiovascular disease closely associated with factors such as
hyperlipidaemia and chronic inflammation. Among them, endothelial dysfunction serves as a …

In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (Fbn1) mutations can lead to
vascular wall weakening and dysfunction. The experimental mouse model of MFS …

Introduction: Ascending aortic aneurysm is a serious health risk. In order to study ascending
aortic aneurysms, elastase and calcium ion treatment for aneurysm formation are mainly …

Mechanical changes to vascular tissues and cells have been long appreciated in
aortopathies, but the cellular mechanisms driving these mechanical pathologies remain …