HER2 is highly expressed in a variety of malignant tumors and affects the prognosis of
patients, making it a highly sensitive target for cancer therapy. Since the approval of the first …

Nano-engineering with unique “custom function” capability has shown great potential in
solving technical difficulties of nanomaterials in tumor treatment. Through tuning the size …

Glioblastoma multiforme (GBM) is a highly aggressive malignant primary tumor in the central
nervous system. Despite extensive efforts in radiotherapy, chemotherapy, and neurosurgery …

Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein.
Piezo1 has various effects and plays an important and irreplaceable role in the maintenance …

Although natural products are essential sources of small‐molecule antitumor drugs, some
can exert substantial toxicities, limiting their clinical utility. Anthraquinone‐fused enediyne …

Estrogen receptor positive breast cancer is a prevalent disease traditionally treated with
hormone therapy which relies on the expression of the estrogen receptor to starve the tumor …

Background Ubiquitination is a targeted protein modification process mediated by
intracellular molecules. UBR1 encodes a protein that binds to unstable N-terminal residues …