Glioblastoma remains as the most common and aggressive malignant brain tumor, standing
with a poor prognosis and treatment prospective. Despite the aggressive standard care …

Abstract Background Coronaviruses such as Severe Acute Respiratory Syndrome
coronavirus (SARS), Middle Eastern Respiratory Syndrome (MERS) and Severe Acute …

Western dietary patterns have been unfavorably linked with mental health. However, the
long-term effects of habitual fried food consumption on anxiety and depression and …

Safe and efficient medical therapy for brain diseases is still an unmet clinical need due to
various barriers represented by the blood-brain barrier. Well-designed brain targeted …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

Leukocyte migration into the central nervous system (CNS) represents a central process in
the development of neurological diseases with a detrimental inflammatory component …

The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

Brain ageing is a complex physiological process that includes several mechanisms. It is
characterized by neuronal/glial dysfunction, alterations in brain vasculature and barriers …

Ischemic stroke is the leading cause of death and disability worldwide, and restoring the
blood flow to ischemic brain tissues is currently the main therapeutic strategy. However …