Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase
family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the …

Objective The purpose of this study was to investigate the effect of moderate-intensity
training on the calcineurin/nuclear factor of activated t-cells (NFAT) pathway and factors …

Background We have previously shown that the deletion of the superoxide scavenger, CuZn
superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an …

We have performed microsecond (μs) molecular dynamics simulation (MDS) to identify
structural mechanisms for sarcolipin (SLN) uncoupling of Ca2+ transport from ATP …

Endothermy is the process by which organisms maintain a constant body temperature
despite dynamic environmental temperatures. There are two mechanisms organisms use to …

Inorganic ions are critical for cellular function and require an efficient mechanism of transport
through the cellular membrane. Most often the transport of ions occurs through proteins …

Aims Sarcolipin (SLN) is a key regulator of sarcoplasmic reticulum calcium‐ATPase
(SERCA) 2a, which handles intracellular calcium re‐uptake. This study was aimed to …

The discovery of allosteric modulators is an emerging paradigm in drug discovery, and
signal transduction is a subtle and dynamic process that is challenging to characterize. We …

Sarcoplasmic reticulum Ca 2+-ATPase (SERCA) is critical for cardiac Ca 2+ transport.
Reversal of phospholamban (PLB)-mediated SERCA inhibition by saturating Ca 2+ …