New developments in the diagnosis and treatment of thyroid cancer

DF Schneider, H Chen - CA: a cancer journal for clinicians, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Thyroid cancer exists in several forms. Differentiated
thyroid cancers include those with papillary and follicular histologies. These tumors exist …

[HTML][HTML] Molecular functions of thyroid hormone signaling in regulation of cancer progression and anti-apoptosis

YC Liu, CT Yeh, KH Lin - International Journal of Molecular Sciences, 2019 - mdpi.com
Several physiological processes, including cellular growth, embryonic development,
differentiation, metabolism and proliferation, are modulated by genomic and nongenomic …

Hesperetin activates the Notch1 signaling cascade, causes apoptosis, and induces cellular differentiation in anaplastic thyroid cancer

PN Patel, XM Yu, R Jaskula-Sztul, H Chen - Annals of surgical oncology, 2014 - Springer
Background Anaplastic thyroid cancer (ATC) is characterized by very aggressive growth with
undifferentiated features. Recently, it has been reported that the Notch1 signaling pathway …

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

VP Kale, JA Hengst, DH Desai, SG Amin, JK Yun - Cancer letters, 2015 - Elsevier
Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we
briefly describe the signal transduction pathways associated with the ROCK and MRCK …

Advances in surgical therapy for thyroid cancer

H Mazeh, H Chen - Nature Reviews Endocrinology, 2011 - nature.com
Thyroid cancer is the most common malignancy of the endocrine system and its incidence
has dramatically increased over the past three decades. Well-differentiated thyroid cancers …

Antiproliferative effect of chrysin on anaplastic thyroid cancer

TA Phan, XM Yu, M Kunnimalaiyaan, H Chen - Journal of Surgical …, 2011 - Elsevier
BACKGROUND: Anaplastic thyroid cancer (ATC) is an undifferentiated, aggressive
malignancy, for which there are no effective therapies. Though ATCs only make up less than …

Signaling mechanisms in neuroendocrine tumors as targets for therapy

B Zarebczan, H Chen - Endocrinology and Metabolism Clinics, 2010 - endo.theclinics.com
Neuroendocrine tumors (NETs) are rare, with an incidence of 2 to 5 per 100,000 people. 1
These tumors secrete hormones such as 5-hydroxytryptamine (5-HT)(serotonin) …

[HTML][HTML] The effect of chronic lymphocytic thyroiditis on patients with thyroid cancer

Y Zhang, X Ma, F Deng, Z Liu, H Wei, X Wang… - World journal of surgical …, 2014 - Springer
Background The purpose of this study was to investigate the association between chronic
lymphocytic thyroiditis (CLT) and malignant tumors of the thyroid. Methods A retrospective …

[HTML][HTML] Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

M Takacova, P Bullova, V Simko, L Skvarkova… - The American journal of …, 2014 - Elsevier
Medullary thyroid carcinoma is a relatively rare tumor with poor prognosis and therapy
response. Its phenotype is determined by both genetic alterations (activating RET …

Identification and validation of novel genes in anaplastic thyroid carcinoma via bioinformatics analysis

S Wang, J Wu, C Guo, H Shang, J Yao… - Cancer Management …, 2020 - Taylor & Francis
Purpose The conventional interventions of anaplastic thyroid carcinoma (ATC) patients are
mainly through surgery, chemotherapy, and radiotherapy; however, it is hardly to improve …