Beyond extracellular vesicles: hybrid membrane nanovesicles as emerging advanced tools for biomedical applications

M Sun, J Yang, Y Fan, Y Zhang, J Sun, M Hu… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs), involved in essential physiological and pathological processes
of the organism, have emerged as powerful tools for disease treatment owing to their unique …

DNA Nanomaterial‐Empowered Surface Engineering of Extracellular Vesicles

X Yao, D He, P Wei, Z Niu, H Chen, L Li… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐secreted biological nanoparticles that are critical
mediators of intercellular communication. They contain diverse bioactive components, which …

Selective In Situ Analysis of Mature microRNAs in Extracellular Vesicles Using a DNA Cage‐Based Thermophoretic Assay

S Zhao, S Zhang, H Hu, Y Cheng, K Zou… - Angewandte …, 2023 - Wiley Online Library
Mature microRNAs (miRNAs) in extracellular vesicles (EVs) are involved in different stages
of cancer progression, yet it remains challenging to precisely detect mature miRNAs in EVs …

An Integrated amplification-free digital CRISPR/Cas-assisted assay for single molecule detection of RNA

D Wang, X Wang, F Ye, J Zou, J Qu, X Jiang - ACS nano, 2023 - ACS Publications
Conventional nucleic acid detection technologies usually rely on amplification to improve
sensitivity, which has drawbacks, such as amplification bias, complicated operation, high …

Controllable Assembly of a Quantum Dot-Based Aptasensor Guided by CRISPR/Cas12a for Direct Measurement of Circulating Tumor Cells in Human Blood

Q Zhang, X Gao, YP Ho, M Liu, Y Han, D Li, H Yuan… - Nano Letters, 2024 - ACS Publications
Accurate and sensitive analysis of circulating tumor cells (CTCs) in human blood provides a
non-invasive approach for the evaluation of cancer metastasis and early cancer diagnosis …

Asymmetrically split DNAzyme-based colorimetric and electrochemical dual-modal biosensor for detection of breast cancer exosomal surface proteins

W Cheng, Y Yao, D Li, C Duan, Z Wang… - Biosensors and …, 2023 - Elsevier
Exosomal surface proteins are potentially useful for breast cancer diagnosis and awareness
of risk. However, some detection techniques involving complex operations and expensive …

Bottom-up signal boosting with fractal nanostructuring and primer exchange reaction for ultrasensitive detection of cancerous exosomes

M Huang, Y Xiang, Y Chen, H Lu, H Zhang, F Liu… - ACS …, 2023 - ACS Publications
Exosomes are emerging as promising biomarkers for cancer diagnosis, yet sensitive and
accurate quantification of tumor-derived exosomes remains a challenge. Here, we report an …

Dual-aptamer recognition of DNA Logic Gate Sensor-based specific exosomal proteins for ovarian Cancer diagnosis

M Zhao, Q Li, Y Zhao, H Zhou, Y Yan, RM Kong… - ACS …, 2024 - ACS Publications
Clinical diagnosis of ovarian cancer lacks high accuracy due to the weak selection of
specific biomarkers along with the circumstance biomarkers localization. Clustering analysis …

Immobilization-free dual-aptamer-based photoelectrochemical platform for ultrasensitive exosome assay

X Liu, H Cheng, Y Zhao, Y Wang, L Ge, Y Huang, F Li - Talanta, 2024 - Elsevier
Exosomes, involved in cancer-specific biological processes, are promising noninvasive
biomarkers for early diagnosis of cancer. Herein, an immobilization-free dual-aptamer …

Dual-microRNA-Controlled Electrochemiluminescence Biosensor for Breast Cancer Diagnosis and Supplemental Identification of Breast Cancer Metastasis

Z Ye, M Ma, Y Chen, R Liu, Y Zhang, P Ma… - Analytical …, 2024 - ACS Publications
Breast cancer remains the most frequently diagnosed cancer globally, and the metastasis of
this malignancy is the primary cause of mortality in breast cancer patients. Hence, prompt …