Five-membered heterocycles are essential structural components in various antibacterial
drugs; the physicochemical properties of a five-membered heterocycle can play a crucial …

Effective antimicrobial exposure is essential to treat infections and prevent antimicrobial
resistance, both being major public health problems in low and middle income countries …

The development of broad-spectrum antibiotics to control multidrug-resistant bacteria is an
outdated business model. This strategy has led to the introduction of highly effective …

Background Temocillin is a narrow spectrum β-lactam active against MDR Enterobacterales.
Mechanisms of acquired resistance to temocillin are poorly understood. We analysed …

Background Temocillin is a β-lactam that is not hydrolysed by ESBLs Objectives To describe
the real-life use of temocillin, to assess its effectiveness in infections caused by ESBL …

Background Temocillin is an interesting alternative to carbapenems for susceptible
Enterobacteriaceae. Although its use in outpatient parenteral antimicrobial therapy (OPAT) …

Objectives Temocillin, a carbapenem-sparing β-lactam antibiotic, is commonly used at the
standard 4 g/day dosage for treating complicated urinary tract infections (cUTIs). However …

Infections caused by KPC-producing K. pneumoniae continue to pose a significant clinical
challenge due to their emerging resistance to new antimicrobials. We investigated the …

Background Antimicrobial stewardship (AMS) is an intervention, which ensures the
appropriateness of antimicrobial use to avoid in part the rising problem of antimicrobial …

Ambulant erworbene, unkomplizierte Harnwegsinfektionen (HWI) stellen eine der häufigsten
Infektionen im ambulanten Bereich dar, insbesondere bei Frauen. 1 Eine antiinfektive …