The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

It has been known for many years that cellular metabolism within the solid tumour is
markedly different from that of the corresponding normal tissue. The transcription factor …

Ecotoxicological effect studies often expose test organisms under optimal environmental
conditions. However, organisms in their natural settings rarely experience optimal …

Reactive oxygen species (ROS) are critically important chemical intermediates in biological
studies, due to their multiple physiologically essential functions and their often pathologically …

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …

Oxygen homeostasis represents an important organizing principle for human development
and physiology. The essential requirement for oxidative phosphorylation to generate ATP is …

The mitochondrion is a major source of reactive oxygen species (ROS). Superoxide (O 2•−)
is generated under specific bioenergetic conditions at several sites within the electron …

The lungs are directly exposed to higher oxygen concentrations than most other tissues.
Increased oxidative stress is a significant part of the pathogenesis of obstructive lung …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …