Significance: A mismatch between energy supply and demand induces tissue hypoxia with
the potential to cause cell death and organ failure. Whenever arterial oxygen concentration …

In stroke research, a significant focus is to develop therapeutic strategies that prevent
neuronal death and improve recovery. Yet, few successful therapeutic strategies have …

Endothelial cell injury and dysfunction are the major triggers of pathophysiological
processes leading to cardiovascular disease. Endothelial dysfunction (ED) has been …

Proliferating cells have a higher metabolic rate than quiescent cells. To investigate the role
of metabolism in cell cycle progression, we examined cell size, mitochondrial mass, and …

Abstract Hereditary paraganglioma type 1 (PGL1) is characterized by slow-growing and
vascularized tumors that often develop in the carotid body (CB) and is caused by mutations …

Three genes encoding for mitochondrial complex II proteins are linked to hereditary
paraganglioma. We have recently shown that an inactivation of the SDHD gene is …

Mussels Perna perna were exposed to air for 24 h showing a clear increase in the levels of
lipid peroxidation and oxidative DNA damage, measured as 8-oxo-7, 8-dihydro-2 …

Abstract The generation of Reactive Oxygen Species (ROS) as by‐products in mitochondria
Electron Transport Chain (ETC) has long been admitted as the cost of aerobic energy …

Research over the last decade has extended the prevailing view of cell mitochondrial
function well beyond its critical bioenergetic role in supplying ATP. Recently, it has been …

Key points Carotid body (CB) glomus cells mediate acute oxygen sensing and the initiation
of the hypoxic ventilatory response, yet the gene expression profile of these cells is not …