Many drugs used for chronic illnesses can contribute to dry eye syndrome, and elderly
patients who have dry eye may concurrently be on systemic medications that worsen the …

The Society of Toxicologic Pathology charged a Nervous System Sampling Working Group
with devising recommended practices to routinely screen the central nervous system (CNS) …

The eye is particularly well suited for local drug delivery due to the size, location, and optical
clarity of tissues and is the mainstay for the treatment of ocular conditions. There are …

Infections by pathogenic Acinetobacter species represent a significant burden on the health
care system, despite their relative rarity, due to the difficulty of treating infections through oral …

As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …

INTRODUCTION: We have evaluated the ability of a semi-automated, optomotor reflex
method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice …

Rapidly and correctly identifying eye irritants or corrosive chemicals is an important issue in
health hazard assessment. The purpose of this study is to describe the development of in …

Regulatory agencies require testing of chemicals and products to protect workers and
consumers from potential eye injury hazards. Animal screening, such as the rabbit Draize …

Lens explant cultures were used to assess the mechanism of drug-induced cataractogenic
potential of NVS001, a peroxisome proliferator–activated receptor delta (PPARδ) agonist …

The identification of microscopic toxicologic changes in eyes is influenced by many factors.
Important factors include in vivo procedures, such as route of administration to the eye, and …