RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
[HTML][HTML] Clinical application of radiolabeled RGD peptides for PET imaging of integrin αvβ3
Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for
clinicians because of the wide-spread application of anti-angiogenic cancer therapeutics …
clinicians because of the wide-spread application of anti-angiogenic cancer therapeutics …
Molecular imaging of the tumor microenvironment
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …
and resistance to therapy. It is different from normal tissue in the extracellular matrix …
Peptide-based imaging agents for cancer detection
Selective receptor-targeting peptide based agents have attracted considerable attention in
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …
Tumour microenvironment responsive nanoconstructs for cancer theranostic
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …
[HTML][HTML] Integrin αvβ3-targeted radionuclide therapy combined with immune checkpoint blockade immunotherapy synergistically enhances anti-tumor efficacy
Rationale: Radiotherapy combined with immunotherapy has revealed promising outcomes
in both preclinical studies and ongoing clinical trials. Targeted radionuclide therapy (TRT) is …
in both preclinical studies and ongoing clinical trials. Targeted radionuclide therapy (TRT) is …
A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate Labeling?
C Fersing, A Bouhlel, C Cantelli, P Garrigue… - Molecules, 2019 - mdpi.com
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron
emission tomography (PET) imaging, for both preclinical and clinical applications. However …
emission tomography (PET) imaging, for both preclinical and clinical applications. However …
The Role of VEGF receptors as molecular target in nuclear medicine for cancer diagnosis and combination therapy
K Masłowska, PK Halik, D Tymecka, A Misicka… - Cancers, 2021 - mdpi.com
Simple Summary The rapid development of diagnostic and therapeutic methods of the
cancer treatment causes that these diseases are becoming better known and the fight …
cancer treatment causes that these diseases are becoming better known and the fight …
Nanodisk-based glioma-targeted drug delivery enabled by a stable glycopeptide
Abstract Heptapeptide ATWLPPR (A7R) binds specifically to vascular endothelial growth
factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) overexpressed in glioma cells …
factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) overexpressed in glioma cells …
Injectable single-component peptide depot: autonomously rechargeable tumor photosensitization for repeated photodynamic therapy
The general practice of photodynamic therapy (PDT) comprises repeated multiple sessions,
where photosensitizers are repeatedly administered prior to each operation of light …
where photosensitizers are repeatedly administered prior to each operation of light …