Antiarrhythmic drug therapy in the treatment of acute and chronic atrial flutter
M Amadori, A Rapacciuolo… - Cardiac …, 2022 - cardiacep.theclinics.com
Atrial flutter is the most common sustained cardiac arrhythmia after atrial fibrillation. It is
classically defined as synchronized supraventricular tachycardia characterized by a regular …
classically defined as synchronized supraventricular tachycardia characterized by a regular …
Predicting the cardiac toxicity of drugs using a novel multiscale exposure–response simulator
F Sahli Costabal, J Yao, E Kuhl - Computer methods in …, 2018 - Taylor & Francis
A common but serious side effect of many drugs is torsades de pointes, a rhythm disorder
that can have fatal consequences. Torsadogenic risk has traditionally been associated with …
that can have fatal consequences. Torsadogenic risk has traditionally been associated with …
[HTML][HTML] The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular …
A Dokuchaev, A Kursanov… - Frontiers in …, 2023 - frontiersin.org
Background: Populations of in silico electrophysiological models of human cardiomyocytes
represent natural variability in cell activity and are thoroughly calibrated and validated using …
represent natural variability in cell activity and are thoroughly calibrated and validated using …
Refractory Torsades de Pointes Due to Dofetilide Overdose
J Crosby, H Bhopalwala, A Kharawala… - … High Impact Case …, 2021 - journals.sagepub.com
Dofetilide, a class III antiarrhythmic, is widely used in the treatment of cardiac arrhythmias.
Antiarrhythmic drugs can have a long duration of action that prolongs the QT interval. This …
Antiarrhythmic drugs can have a long duration of action that prolongs the QT interval. This …
[HTML][HTML] Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction
C Citerni, J Kirchhoff, LH Olsen, SM Sattler… - Frontiers in …, 2020 - frontiersin.org
Background Inhibition of KCa2 channels, conducting IKCa, can convert atrial fibrillation (AF)
to sinus rhythm and protect against its induction. IKCa inhibition has been shown to possess …
to sinus rhythm and protect against its induction. IKCa inhibition has been shown to possess …
[引用][C] Inhibition of K Ca 2 and K v 11.1 Channels in Pigs With Left Ventricular Dysfunction
M Grunnet, N Edvardsson, BH Bentzen, JG Diness