Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with
conventional risk factor control, significant residual risk remains. Recent evidence on non …

Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still
incompletely understood. Although traditionally considered a thermogenic tissue, brown …

Lactate is a circulating metabolite and a signalling molecule with pleiotropic physiological
effects. Studies suggest that lactate modulates energy balance by lowering food intake …

We propose a weight-neutral strategy for obesity treatment on the following grounds:(1) the
mortality risk associated with obesity is largely attenuated or eliminated by moderate-to-high …

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver
disease, are characterized by chronic low-grade tissue and systemic inflammation. During …

Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic
diseases risk. This led to the idea that exercise-induced muscle contraction contributes to …

Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT)
physiology in rodents housed below their thermoneutral zone (ie, 28–32° C). In these …

Increased physical activity is an optimal way to maintain a good health. During exercise,
triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fatty acids …

As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In
adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT …