Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
Electrochemical methods for the analysis of clinically relevant biomolecules
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …
demand for high-performance detection technologies. Implementation of electrochemical …
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
The DNA mutation produced by cellular repair of a CRISPR–Cas9-generated double-strand
break determines its phenotypic effect. It is known that the mutational outcomes are not …
break determines its phenotypic effect. It is known that the mutational outcomes are not …
Microsatellites, from molecules to populations and back
P Jarne, PJL Lagoda - Trends in ecology & evolution, 1996 - cell.com
H istory sometimes takes ironical twists, and the history of science is no exception.
Microsatellites have been detected in eukaryote genomes for over 15 years, though they …
Microsatellites have been detected in eukaryote genomes for over 15 years, though they …
[图书][B] DNA fingerprinting in plants: principles, methods, and applications
Given the explosive development of new molecular marker techniques over the last decade,
newcomers and experts alike in the field of DNA fingerprinting will find an easy-to-follow …
newcomers and experts alike in the field of DNA fingerprinting will find an easy-to-follow …
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator ofCFTR exon 9
E Buratti, FE Baralle - Journal of Biological Chemistry, 2001 - ASBMB
Variations in a polymorphic (TG) m sequence near exon 9 of the human CFTR gene have
been associated with variable proportions of exon skipping and occurrence of disease. We …
been associated with variable proportions of exon skipping and occurrence of disease. We …
[图书][B] Chromatin: structure and function
A Wolffe - 1998 - books.google.com
The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …
remarkable progress in chromatin research over the past three years. It has been …
Microsatellite mutations in the germline:: implications for evolutionary inference
H Ellegren - Trends in genetics, 2000 - cell.com
Microsatellite DNA sequences mutate at rates several orders of magnitude higher than that
of the bulk of DNA. Such high rates mean that spontaneous mutations that form new-length …
of the bulk of DNA. Such high rates mean that spontaneous mutations that form new-length …
Nearest-Neighbor Thermodynamics and NMR of DNA Sequences with Internal A⊙ A, C⊙ C, G⊙ G, and T⊙ T Mismatches
N Peyret, PA Seneviratne, HT Allawi, J SantaLucia - Biochemistry, 1999 - ACS Publications
Thermodynamic measurements are reported for 51 DNA duplexes with A⊙ A, C⊙ C, G⊙ G,
and T⊙ T single mismatches in all possible Watson− Crick contexts. These measurements …
and T⊙ T single mismatches in all possible Watson− Crick contexts. These measurements …
Simple sequence repeats as a source of quantitative genetic variation
Y Kashi, D King, M Soller - Trends in genetics, 1997 - cell.com
Most traits in biological populations appear to be under stabilizing selection, which acts to
eliminate quantitative genetic variation. Yet, virtually all measured traits in biological …
eliminate quantitative genetic variation. Yet, virtually all measured traits in biological …