[HTML][HTML] Quinolizidine alkaloid biosynthesis in lupins and prospects for grain quality improvement

KM Frick, LG Kamphuis, KHM Siddique… - Frontiers in plant …, 2017 - frontiersin.org
Quinolizidine alkaloids (QAs) are toxic secondary metabolites found within the genus
Lupinus, some species of which are commercially important grain legume crops including …

[HTML][HTML] The effects of domestication on secondary metabolite composition in legumes

YS Ku, CA Contador, MS Ng, J Yu, G Chung… - Frontiers in …, 2020 - frontiersin.org
Legumes are rich in secondary metabolites, such as polyphenols, alkaloids, and saponins,
which are important defense compounds to protect the plant against herbivores and …

[HTML][HTML] Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation

D Mancinotti, KM Frick, F Geu-Flores - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Quinolizidine alkaloids (QAs) are a class of alkaloids that accumulate
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …

Applications of Knoevenagel condensation reaction in the total synthesis of natural products

MM Heravi, F Janati, V Zadsirjan - Monatshefte für Chemie-Chemical …, 2020 - Springer
The Knoevenagel condensation reaction is a prominent organic reaction commonly being
utilized in the total synthesis of natural and biologically potent products as a vital and …

(−)-Cytisine and derivatives: synthesis, reactivity, and applications

J Rouden, MC Lasne, J Blanchet, J Baudoux - Chemical reviews, 2014 - ACS Publications
(−)-Cytisine (−)-1,[(1R, 5S)-1, 2, 3, 4, 5, 6-hexahydro-1, 5-methano-8H-pyrido [1, 2a][1, 5]
diazocin-8-one (Figure 1), is an alkaloid extracted from various plants belonging to the …

Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae

S Bunsupa, K Katayama, E Ikeura, A Oikawa… - The Plant …, 2012 - academic.oup.com
Lysine decarboxylase (LDC) catalyzes the first-step in the biosynthetic pathway of
quinolizidine alkaloids (QAs), which form a distinct, large family of plant alkaloids. A cDNA of …

A pyridine dearomatization approach to the matrine-type lupin alkaloids

JK Kerkovius, A Stegner, A Turlik, PH Lam… - Journal of the …, 2022 - ACS Publications
(+)-Matrine and (+)-isomatrine are tetracyclic alkaloids isolated from the plant Sophora
flavescens, the roots of which are used in traditional Chinese medicine. Biosynthetically …

Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor

J Zhao, CC Williams, RL Last - The Plant Cell, 1998 - academic.oup.com
The tryptophan (Trp) biosynthetic pathway leads to the production of many secondary
metabolites with diverse functions, and its regulation is predicted to respond to the needs for …

[HTML][HTML] Quinolizidine alkaloid biosynthesis: recent advances and future prospects

S Bunsupa, M Yamazaki, K Saito - Frontiers in plant science, 2012 - frontiersin.org
Lys-derived alkaloids, including piperidine, quinolizidine, indolizidine, and lycopodium
alkaloids, are widely distributed throughout the plant kingdom. Several of these alkaloids …

Enantioselective synthesis of piperidine, indolizidine, and quinolizidine alkaloids from a phenylglycinol-derived δ-lactam

M Amat, N Llor, J Hidalgo, C Escolano… - The Journal of Organic …, 2003 - ACS Publications
Starting from a common lactam,(3 R, 8a S)-5-oxo-3-phenyl-2, 3, 6, 7, 8, 8a-hexahydro-5 H-
oxazolo [3, 2-a] pyridine (1), or its enantiomer, the enantioselective synthesis of 2 …