Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Introduction Vascular calcification (VC) which is the pathological mineral deposition in the
vascular system, predominantly at the intimal and medial layer of the vessel wall, is an …

α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered
circulating soluble α-Klotho levels have been observed in aged non-healthy individuals, no …

Background and aims Abdominal aortic calcification (AAC) has been recognized as an
independent predictor of cardiovascular disease (CVD) incidence and mortality. The aim of …

Introduction Studies on association of α-klotho levels with mortality risk in general population
are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort …

We conducted a systematic search across medical databases, including PubMed, Web of
Science, EMBASE, and Cochrane Library, up to March 2023. A total of 1944 subjects or …

Background While it is known that klotho has negative regulatory effects in a variety of
diseases such as metabolic disorders and kidney disease, the specific role of klotho in …

Background: Abdominal aortic calcification (AAC) is considered an independent predictor of
cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular …

Background Vascular calcification (VC) is suggested to be associated with serum klotho
levels in patients with maintenance hemodialysis (MHD), whereas there is a lack of reports …

血管钙化是慢性肾脏病(CKD) 最常见的并发症之一, 是影响CKD 患者预后的主要因素.
血管钙化的早期诊断, 及时干预和进展评估对于改善预后至关重要. 近些年 …