Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
A Ray Chaudhuri, A Nussenzweig - Nature reviews Molecular cell …, 2017 - nature.com
Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …
which, if unrepaired, impairs genome integrity and leads to the development of various …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Poly (ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response
targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism …
targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism …
RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …
important biological roles and are implicated in pathology. Even so, proteins recognizing …
Biomarker-guided development of DNA repair inhibitors
JM Cleary, AJ Aguirre, GI Shapiro, AD D'Andrea - Molecular cell, 2020 - cell.com
Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional
defects in this pathway through synthetic lethal mechanisms. For example, defects in …
defects in this pathway through synthetic lethal mechanisms. For example, defects in …
DNA damage response in cancer therapy and resistance: challenges and opportunities
D Jurkovicova, CM Neophytou, AČ Gašparović… - International Journal of …, 2022 - mdpi.com
Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …
reason why new cancer therapies and therapeutic strategies need to be in continuous …
Targeting topoisomerase I in the era of precision medicine
Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years.
Because of their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage …
Because of their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage …
Mechanisms of DNA–protein crosslink repair
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …