Csnk1e, the gene encoding casein kinase 1-epsilon, has been implicated in sensitivity to
amphetamines. Additionally, a polymorphism in CSNK1E was associated with heroin …

Objective Most drugs of abuse have both aversive and rewarding effects, and the use and
abuse potential of such drugs is thought to be a function of a balance of these affective …

Synthetic combinatorial methods now make it practical to readily produce hundreds of
thousands of individual compounds, but it is clearly impractical to screen each separately in …

Synthetic cathinones, otherwise known as “bath salts”, have gained significant attention in
the last few years as a result of increased use and abuse. One such compound, 3, 4 …

Chronic opioid treatments dysregulate the glutamatergic system, inducing a
hyperglutamatergic state in mesocorticolimbic brain regions. This study investigated the …

Recently, it was shown that d-cycloserine (DCS, a NMDA partial agonist) facilitated
extinction of fear as well as cocaine conditioned place preference (CPP) in rats. METHODS …

The constitutively expressed (CC) Homer protein Homer2a/b actively regulates behavioral
and neurochemical sensitivity to cocaine in both rats and mice. The present study employed …

Impulsivity is a defining characteristic of adolescence. Compared to adults, for example,
adolescents engage in higher rates of drug and alcohol experimentation, risky sexual …

Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …

The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is
increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized …