Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …

Contraction in striated muscle is initiated by calcium binding to troponin complexes, but it is
now understood that dynamic transition of myosin between resting, ordered OFF states on …

Heart muscle has the unique property that it can never rest; all cardiomyocytes contract with
each heartbeat which requires a complex control mechanism to regulate cardiac output to …

Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …

Ethosuximide (ETX) is a common drug in the treatment of absence epilepsy. ETX is known to
act via inhibition of T-type voltage gated Ca2þ channels. Later, it was shown that ETX blocks …

Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle
disorders. NM is often associated with mutations in the NEB gene. Even though the exact …

Proline substitutions within the coiled-coil rod region of the β-myosin gene (MYH7) are the
predominant mutations causing Laing distal myopathy (MPD1), an autosomal dominant …

Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …