Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Patients with sepsis present across a spectrum of infection sites and severity of illnesses
requiring complex decision making at the bedside as to when prompt antibiotics are …

Early appropriate antimicrobial therapy is crucial in patients with sepsis and septic shock.
Studies often focus on time to first dose of appropriate antibiotics, but subsequent dosing is …

Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and
aggressive interventions are essential for improving clinical outcomes. There are a number …

Sepsis is a major cause of hospital death in the United States (US) 1 and is associated with
over 850,000 annual emergency department visits. 2 Despite advances in care, patients with …

Objectives: Because of overcrowding and limited critical care resources, critically ill patients
in the emergency department may spend hours to days awaiting transfer to the ICU. In these …

Background: While vancomycin loading doses may facilitate earlier pharmacokinetic–
pharmacodynamic target attainment, the impact of loading doses on clinical outcomes …

Trauma is a leading cause of death in the United States for people under 45. Amongst
trauma-related injuries, orthopedic injuries represent a significant component of trauma …

Background Early antibiotics are fundamental to sepsis management. Second-dose
antibiotic delays were associated with increased mortality in a recent study. Study objectives …