Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Comprehensively mapping the genetic basis of human disease across diverse individuals is
a long-standing goal for the field of human genetics 1–4. The All of Us Research Program is …

Global genomic diversity for All of Us | Nature Reviews Genetics Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Although we commend the American College of Medical Genetics and Genomics (ACMG)
on their efforts to summarize the state of preimplantation genetic testing for polygenic …

The differential performance of polygenic risk scores (PRSs) by group is one of the major
ethical barriers to their clinical use. It is also one of the main practical challenges for any …

Comprehensively mapping the genetic basis of human disease across diverse individuals is
a long-standing goal for the field of human genetics,,–. The All of Us Research Program is a …

Glaucoma, the most common cause of irreversible blindness worldwide is one of the most
heritable of all complex human diseases with an estimated heritability of 70%[1]. Diagnosis …

Background: Despite monogenic and polygenic contributions to cardiovascular disease
(CVD), genetic testing is not widely adopted, and current tests are limited by the breadth of …

Importance: By integrating genetic and clinical risk factors into genomic-informed dementia
risk reports, healthcare providers can offer patients detailed risk profiles to facilitate …

Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, yet existing methods face a tradeoff between predictive power and …