ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

The influence of pharmacogenetics in tacrolimus pharmacokinetics and pharmacodynamics
needs further investigation, considering its potential in assisting clinicians to predict the …

Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine
synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic …

Membrane transport proteins are potential targets for medical and biotechnological
applications. However, more than 30% of reported membrane transporter families are either …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

Plants developed sophisticated mechanisms to perceive environmental stimuli and generate
appropriate signals to maintain optimal growth and stress responses. A fascinating strategy …

Organisms maintain metabolic homeostasis through the combined functions of small-
molecule transporters and enzymes. While many metabolic components have been well …

Blocking the import of nutrients essential for cancer cell proliferation represents a
therapeutic opportunity, but it is unclear which transporters to target. Here we report a …

One of the greatest challenges with successful pharmaceutical treatments of central nervous
system (CNS) diseases is the delivery of drugs into their target sites with appropriate …