BACKGROUND & AIMS: Hypervigilance is considered important in pain perception in
functional gastrointestinal disorders. Nonetheless, a comprehensive assessment of the …

In heterozygous mice, attenuation of G-protein-coupled receptor kinase 2 (GRK2) level in
nociceptors is associated with enhanced and prolonged inflammatory hyperalgesia. To …

In the present study we examined whether the descending facilitation from the rostral
ventromedial medulla (RVM) is required for the enhancement of formalin-evoked …

Analgesic efficacy varies depending on the pain syndrome being treated. One reason for
this may be a differential effect of individual pain syndromes on the function of the …

Background: Fibromyalgia (FM) is characterized by chronic widespread pain, which is often
refractory to conventional painkillers. Numerous clinical studies have demonstrated that …

Epidemiological studies have shown a close association between pain and depression.
There is evidence showing this association as patients with depression show a high chronic …

Experimental hypoglycemia leads to heightened cutaneous sensitivity, increases to thermal
temporal summation, and elevated proinflammatory cytokines, catecholamines and …

The use of blood corticosterone and faecal corticosterone metabolites as biomarkers of post-
surgical stress and pain in laboratory animals has increased during the last decade …

Background Reports show that stressful events before injury exacerbates post-injury pain.
The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we …

Study Design Prospective human cohort study combined with molecular studies.
Background A microRNA is a small, noncoding RNA molecule that can play a role in …