Polymyxin triple combinations against polymyxin-resistant, multidrug-resistant, KPC-producing Klebsiella pneumoniae
Resistance to polymyxin antibiotics is increasing. Without new antibiotic classes,
combination therapy is often required. We systematically investigated bacterial killing with …
combination therapy is often required. We systematically investigated bacterial killing with …
Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model
SKB Sy, L Zhuang, ME Beaudoin… - Journal of …, 2017 - academic.oup.com
Objectives: This study evaluated the in vitro pharmacodynamics of combinations of
ceftazidime and the non-β-lactam β-lactamase inhibitor, avibactam, against ceftazidime …
ceftazidime and the non-β-lactam β-lactamase inhibitor, avibactam, against ceftazidime …
New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver …
Increasing evidence suggests that colistin monotherapy is suboptimal at currently
recommended doses. We hypothesized that front-loading provides an improved dosing …
recommended doses. We hypothesized that front-loading provides an improved dosing …
Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical …
X Liu, C Huang, PJ Bergen, J Li, J Zhang… - Journal of Zhejiang …, 2023 - Springer
Polymyxin B, which is a last-line antibiotic for extensively drug-resistant Gram-negative
bacterial infections, became available in China in Dec. 2017. As dose adjustments are …
bacterial infections, became available in China in Dec. 2017. As dose adjustments are …
[HTML][HTML] In vitro and in vivo assessment of the antibacterial activity of colistin alone and in combination with other antibiotics against Acinetobacter baumannii and …
Y Wang, H Li, X Xie, XH Wu, X Li, Z Zhao, S Luo… - Journal of Global …, 2020 - Elsevier
Objectives Limited therapeutic options exist for treating severe infections caused by
multidrug-resistant (MDR) and extensively drug-resistant Gram-negative bacteria (GNB). In …
multidrug-resistant (MDR) and extensively drug-resistant Gram-negative bacteria (GNB). In …
Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate
M Hecht, R Veigure, L Couchman, CI S Barker… - Bioanalysis, 2018 - Taylor & Francis
Traditionally, bioanalytical laboratories do not report actual concentrations for samples with
results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method …
results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method …
Optimization of polymyxin B in combination with doripenem to combat mutator Pseudomonas aeruginosa
Development of spontaneous mutations in Pseudomonas aeruginosa has been associated
with antibiotic failure, leading to high rates of morbidity and mortality. Our objective was to …
with antibiotic failure, leading to high rates of morbidity and mortality. Our objective was to …
Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies
Remote loading of azithromycin into liposomes, and subsequent release behavior in the
presence of colistin, has been investigated with a view to understand the potential of …
presence of colistin, has been investigated with a view to understand the potential of …
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems …
S López-Argüello, M Montaner… - Antimicrobial agents …, 2023 - Am Soc Microbiol
The β-lactam antibiotics have been successfully used for decades to combat susceptible
Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane …
Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane …
In vivo activity of vancomycin combined with colistin against multidrug-resistant strains of Acinetobacter baumannii in a Galleria mellonella model
H Yang, N Lv, L Hu, Y Liu, J Cheng, Y Ye, J Li - Infectious diseases, 2016 - Taylor & Francis
Background: With increasing antibiotic resistance, the selection of effective treatment of A.
baumannii infections is particularly challenging. Methods: This study assessed the activities …
baumannii infections is particularly challenging. Methods: This study assessed the activities …