The accurate prediction of binding between T cell receptors (TCR) and their cognate
epitopes is key to understanding the adaptive immune response and developing …

Renal cell carcinoma (RCC) is a heterogeneous group of kidney cancers with clear cell
RCC (ccRCC) as the major subgroup. To expand the number of clinically relevant tumor …

Efficient antigen presentation is a prerequisite for the development of a T-cell-mediated
immune response in vitro and in vivo. CD40-activated B cells (CD40B cells) are a promising …

For decades, vaccines have played a significant role in protecting public and personal
health against infectious diseases and proved their great potential in battling cancers as …

The emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of
recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Biomarkers …

There has been a growing interest in the use of B cells for cancer vaccines, since they have
yielded promising results in preclinical animal models. Contrary to dendritic cells (DCs), we …

Background Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell
non-Hodgkin's lymphoma often associated with poor prognosis. New therapeutic …

Cyclin D1 is over-expressed in various human tumors and therefore can be a potential
oncogenic target antigen. However, only a limited number of T cell epitopes has been …

The mechanisms of immune evasion during haematological malignancies are poorly
understood. As lymphomas grow in lymphoid organs, it would be expected that if these …

Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent
relevant target molecules for tumor therapy. Among these targets the cyclins are of particular …