It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty
in understanding speech and other sounds. Auditory system dysfunction, including deafness …

Abstract Adenosine A 2A-receptors (A 2A R) and dopamine D 2-receptors (D 2 R) are known
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …

Astrocytes are wired to bidirectionally communicate with neurons namely with synapses,
thus shaping synaptic plasticity, which in the hippocampus is considered to underlie …

Anxiety disorders are common psychiatric conditions with a partially elucidated
neurobiology. Caffeine, an unspecific adenosine receptor antagonist, is a common …

Introduction: Caffeine and the selective A2A receptor antagonist SCH58261 both have
ergogenic properties, effectively reducing fatigue and enhancing exercise capacity. This …

The function of almost all cells of the human and animal body is synchronized by purinergic/
pyrimidinergic extracellular signaling molecules. This network activity is especially efficient …

Chemotherapy has a significant positive impact in cancer treatment outcomes, reducing
recurrence and mortality. However, many cancer surviving children and adults suffer from …

Adenosine receptors (ARs) are being explored to generate non-opioid pain therapeutics.
Vanilloid compounds, curcumin, capsaicin, and vanillin possess antinociceptive properties …

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer's
disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of …