Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds

L Scorzoni, F Sangalli-Leite… - Journal of …, 2016 - Elsevier
In the last decades, the increased number of immunocompromised patients has led to the
emergence of many forms of fungal infections. Furthermore, there are a restricted arsenal of …

Antimicrobial Activity of Heterotrophic Bacterial Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae)

AP Graça, J Bondoso, H Gaspar, JR Xavier… - PLoS …, 2013 - journals.plos.org
Heterotrophic bacteria associated with two specimens of the marine sponge Erylus
discophorus were screened for their capacity to produce bioactive compounds against a …

Dectin-2-targeted antifungal liposomes exhibit enhanced efficacy

S Ambati, EC Ellis, J Lin, X Lin, ZA Lewis, RB Meagher - MSphere, 2019 - Am Soc Microbiol
Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus cause life-
threatening candidiasis, cryptococcosis, and aspergillosis, resulting in several hundred …

β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for …

R Vartak, M Patki, S Menon, J Jablonski… - International Journal of …, 2020 - Elsevier
Epidemiological findings have discussed recurrent and persistent vulvovaginal candidiasis
to be a major manifestation of HIV infected women. Conversely, women with vulvovaginal …

Bioactivities of nano-scale magnesium oxide prepared using aqueous extract of Moringa oleifera leaves as green agent

H Amrulloh, A Fatiqin, W Simanjuntak… - Advances in Natural …, 2021 - iopscience.iop.org
In this research, nano-size MgO (NS-MgO) was prepared from MgCl 2 solution using
aqueous extract of Moringa oleifera leaves (AEMOL) as green agent. Preparation procedure …

Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library

DJM Cruz, RM Bonotto, RGB Gomes… - PLoS neglected …, 2013 - journals.plos.org
Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute
febrile illness in humans accompanied by joint pains and in many cases, persistent …

Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents

V González-Menéndez, G Crespo, N De Pedro… - Scientific reports, 2018 - nature.com
Native plant communities from arid areas present distinctive characteristics to survive in
extreme conditions. The large number of poorly studied endemic plants represents a unique …

Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges

JD Santos, I Vitorino, M De la Cruz, C Díaz… - Frontiers in …, 2019 - frontiersin.org
In the beginning of the twenty-first century, humanity faces great challenges regarding
diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in …

Deciphering Staphylococcus xylosus and Staphylococcus equorum mode of action against Penicillium nordicum in a dry-cured ham model system

E Cebrián, E Roncero, J Delgado, F Núñez… - International Journal of …, 2023 - Elsevier
Penicillium nordicum is one of the major producers of ochratoxin A (OTA) in dry-cured ham.
Staphylococcus xylosus Sx8 and Staphylococcus equorum Se31 have been previously …

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

K Jojić, F Gherlone, Z Cseresnyés, AU Bissell… - Mbio, 2024 - Am Soc Microbiol
Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl
transferases, enzymes responsible for the first step in the sphingolipid biosynthesis …