Perioperative neurocognitive disorder: state of the preclinical science
The purpose of this article is to provide a succinct summary of the different experimental
approaches that have been used in preclinical postoperative cognitive dysfunction research …
approaches that have been used in preclinical postoperative cognitive dysfunction research …
Current methods to investigate nociception and pain in zebrafish
N Ohnesorge, C Heinl, L Lewejohann - Frontiers in Neuroscience, 2021 - frontiersin.org
Pain is an unpleasant, negative emotion and its debilitating effects are complex to manage.
Mammalian models have long dominated research on nociception and pain, but there is …
Mammalian models have long dominated research on nociception and pain, but there is …
Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia
Traditionally, drug dosing is based on a concentration-response relationship estimated in a
population. Yet, in specific individuals, decisions based on the population-level effects …
population. Yet, in specific individuals, decisions based on the population-level effects …
Apoptotic mechanism of propofol-induced developmental toxicity in zebrafish embryos
Y Ge, W Yuan, W Jia, Z Guan, T Huang, Y Zhang… - Plos one, 2023 - journals.plos.org
General anesthetics can cause neurological damage and long-term behavioral/cognitive
impairment during fetal and early postnatal life. However, the adverse influence on embryo …
impairment during fetal and early postnatal life. However, the adverse influence on embryo …
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy
Synapses are particularly vulnerable in many neurodegenerative diseases and often the first
to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA) …
to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA) …
Photomotor responses in zebrafish and electrophysiology reveal varying interactions of anesthetics targeting distinct sites on γ-aminobutyric acid type A receptors
H Hoyt, RJ Fantasia, K Bhave, X Yang, SA Forman - Anesthesiology, 2022 - pubs.asahq.org
Background Etomidate, barbiturates, alfaxalone, and propofol are anesthetics that
allosterically modulate γ-aminobutyric acid type A (GABAA) receptors via distinct sets of …
allosterically modulate γ-aminobutyric acid type A (GABAA) receptors via distinct sets of …
Synthesis and evaluation of avermectin–imidazo [1, 2-a] pyridine hybrids as potent GABAA receptor modulators
YA Volkova, IV Rassokhina, EA Kondrakhin… - Bioorganic …, 2022 - Elsevier
The γ-aminobutyric acid type A (GABA A) receptors are pentameric transmembrane protein
complexes. They have attracted extensive attention from the scientific community due to their …
complexes. They have attracted extensive attention from the scientific community due to their …
Flumazenil-insensitive benzodiazepine binding sites in GABAA receptors contribute to benzodiazepine-induced immobility in zebrafish larvae
Y Cao, H Yan, G Yu, R Su - Life sciences, 2019 - Elsevier
Abstract Aims Benzodiazepines (BZDs) produce various pharmacological actions by binding
to and allosterically regulating GABA A receptors. Several in vitro studies have …
to and allosterically regulating GABA A receptors. Several in vitro studies have …
Drug-selective anesthetic insensitivity of zebrafish lacking γ-aminobutyric acid type A receptor β3 subunits
Abstract Editor's Perspective What We Already Know about This Topic β3 subunits of the γ-
aminobutyric acid type A (GABAA) receptor play a central role in mediating hypnotic and …
aminobutyric acid type A (GABAA) receptor play a central role in mediating hypnotic and …
Synthesis and Structure of Novel Phenothiazine Derivatives, and Compound Prioritization via In Silico Target Search and Screening for Cytotoxic and Cholinesterase …
Phenothiazines (PTZ) are antipsychotics known to modulate a variety of neurotransmitter
activities that include dopaminergic and cholinergic signaling and have been identified as …
activities that include dopaminergic and cholinergic signaling and have been identified as …