Despite more than 5 decades of study and debate, the role of corticosteroid treatment in
patients with severe sepsis and septic shock remains controversial. Data support a …

Rationale Use of etomidate in the critically ill is controversial due to its links with an
inadequate response to corticotropin and potential for excess mortality. In a septic shock …

Objectives: To review the history of clinical use of corticosteroids with particular reference to
adjunctive therapy for severe pediatric sepsis and, in this context, to provide an overview of …

Introduction Circulatory failure during brain death organ donor resuscitation is a problem
that compromises recovery of organs. Combined administration of steroid, thyroxine and …

Objective: To evaluate the effects of hydrocortisone on microcirculatory blood flow
alterations in patients with septic shock. Design: Prospective, open-label study. Setting: A 31 …

Background: Little information exists on the hypothalamic‐pituitary‐adrenal axis in septic
foals. Hypothesis: The plasma concentrations of adrenocorticotropin (ACTH) and cortisol are …

Etomidate is an induction agent known for its smooth intubating conditions and
cardiovascular stability. Studies, however, have shown that a single dose of etomidate can …

Objective One of the most common dynamic testing procedures for assessment of
adrenocortical function is the standard corticotropin or the cosyntropin test. The aim of this …

Purpose: The Surviving Sepsis Campaign guidelines recommend hydrocortisone in septic
shock only when fluid resuscitation and vasopressors fail to restore hemodynamic stability …

Dysfunction of the hypothalamo-pituitary adrenal axis has become a central feature in
descriptions of the pathophysiology of sepsis. However, despite hundreds of published …