Clinical trials of adoptively transferred CD19 chimeric antigen receptor (CAR) T cells have
delivered unprecedented responses in patients with relapsed refractory B-cell malignancy …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

We describe a de novo computational approach for designing proteins that recapitulate the
binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid …

A method to produce αβ T-cell receptors (TCRs) in a soluble form suitable for biophysical
analysis was devised involving in vitro refolding of a TCR fusion protein. Polypeptides …

We used luminescent CdSe− ZnS core− shell quantum dots (QDs) as energy donors in
fluorescent resonance energy transfer (FRET) assays. Engineered maltose binding protein …

A novel and direct method is described for conjugating protein molecules to luminescent
CdSe− ZnS core− shell nanocrystals (Quantum Dots) for use as bioactive fluorescent probes …

Integrin α5β1 is a major cellular receptor for the extracellular matrix protein fibronectin and
plays a fundamental role during mammalian development. A crystal structure of the α5β1 …

We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the
widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this …

Antigen-specific T helper cells present in peripheral blood at very low frequencies are
capable of rapid clonal expansion during antigenic challenge. The exquisite specificity of …

The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue
foreign peptide antigen, and the I-Ak self major histocompatibility complex (MHC) class II …