This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Purpose Although clozapine was Food and Drug Administration (FDA) approved more than
3 decades ago, major barriers and gaps in knowledge continue to prevent its effective and …

Clozapine is a highly efficacious antipsychotic medication and is the standard of care for
treatment-resistant schizophrenia (TRS) 1 as well as for reducing the risk of suicidal …

Current guidelines for the treatment of patients with schizophrenia advocate that patients
receive treatment with a long-acting injectable (LAI) antipsychotic medication if they prefer …

Although uncommon, the risk of aggression and violence is greater in people with
schizophrenia than in the general population. Clozapine is the “gold standard” …

Introduction Agitation is commonly encountered in people with bipolar disorder, particularly
when experiencing a manic episode. The number of approved pharmacological agents to …

Agitation in schizophrenia: origins and evidence-based treat... : Current Opinion in Psychiatry
Agitation in schizophrenia: origins and evidence-based treatment : Current Opinion in …

Abstract A Density Functional Theory study was carried out to obtain quantitative
relationships between the electronic structure of a group of (S)-enantiomers of 11-(1, 6 …

Introduction Clozapine is the gold standard treatment for treatment resistant schizophrenia,
however adverse events remain a clinical challenge. Areas Covered This review presents a …

Interpersonal violent behavior by any measure is a top-tier public health problem in the
United States, accounting for nearly 180,000 fatalities and an estimated 16 million nonfatal …