Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …

The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …

Body axis formation in vertebrate development entails the remarkable feat of patterning a
myriad of specialized cell types and organ progenitors from a field of unpatterned …

During vertebrate development, embryonic cells pass through a continuum of transitory
pluripotent states that precede multi-lineage commitment and morphogenesis. Such states …

Cytochrome P45011A1, encoded by Cyp11a1, converts cholesterol to pregnenolone (P5),
the first and rate-limiting step in steroidogenesis. In zebrafish, cyp11a1 is maternally …

Many maternal mRNAs are translationally repressed during oocyte development and spatio-
temporally activated during early embryogenesis, which is crucial for oocyte and early …

Zebrafish are an effective vertebrate model to study the mechanisms underlying recovery
after spinal cord injury. The subacute phase after spinal cord injury is critical to the recovery …

Maternal products are exclusive factors to drive oogenesis and early embryonic
development. As disrupting maternal gene functions is either time-consuming or technically …

The early development of zebrafish (Danio rerio) is a complex and dynamic physiological
process involving cell division, differentiation, and movement. Currently, the genome and …

Maternal-to-zygotic transition (MZT) is central to early embryogenesis. However, its
underlying molecular mechanisms are still not well described. Here, we revealed the …