Healthy human lungs have traditionally been considered to be a sterile organ. However,
culture-independent molecular techniques have reported that large numbers of microbes …

Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary …

Although the notion that “the normal lung is free from bacteria” remains common in
textbooks, it is virtually always stated without citation or argument. The lungs are constantly …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in
national guidelines for bronchiectasis and is a major focus of drug development and clinical …

Culture-independent microbiological techniques have shown a previously unappreciated
complexity to the bacterial microbiome of the respiratory tract that forces reconsideration of …

Understanding the significance of bacterial species that colonize and persist in cystic fibrosis
(CF) airways requires a detailed examination of bacterial community structure across a …

Background Infection is a key component of bronchiectasis pathophysiology.
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …

Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of
the bronchi and is characterised by chronic infection and associated inflammation. The …