Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Importance The assessment of new antithrombotic agents with a favorable safety profile is
clinically relevant. Objective To test the efficacy and safety of revacept, a novel, lesion …

Platelet glycoprotein VI (GPVI) is attracting interest as a potential target for the development
of new antiplatelet molecules with a low bleeding risk. GPVI binding to vascular collagen …

Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …

The function of platelets–and thereby the balance between thrombosis and hemostasis–
critically depends on their lipid composition. At the same time, platelets are capable of …

Rationale: Platelet activation after contact to subendothelial collagen leads to acute arterial
thrombosis. ANXA7 (Annexin A7) is a phospholipid-binding protein participating in the …

Antiplatelet therapy aims to reduce the risk of thrombotic events while maintaining
hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI …

Objectives Platelet activation underpins thrombus formation in ischemic stroke. The active,
dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet …

Introduction: Luteolin inhibits platelet activation and thrombus formation, but the
mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated …