Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical
cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated …

Alternative splicing has essential roles in development. Remarkably, spermatogenic cells
express more alternatively spliced RNAs compared to most whole tissues; however …

The anti-diabetic drug metformin is thought to be the pharmaceutical most deposited into the
aquatic environment by mass at up to 6 tons per year from individual WWTPs in urban areas …

The estrogenic chemical 4-nonylphenol (NP) is known to impair testicular devolopment and
spermatogenesis in rodents. The objective of this study was to explore the effects of NP on …

Sertoli cells (SCs) support and nourish germ cells (GCs) through their crosstalk during
spermatogenesis. However, the underlying epigenetic mechanism that ensures SCs' …

Abstract The miR-17-92 cluster and its 6 different mature microRNAs, including miR-17, miR-
18a, miR-19a, miR-20a, miR-19b-1, and miR-92a, play important roles in embryo …

Epithelial ovarian cancer presents mostly with serous, endometrioid or mucinous histology
but is treated as a single disease. The development of histotype-specific therapy has been …

The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal
cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the …

LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is
mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers …

Bisphenol S (BPS) is now used as an alternative of bisphenol A (BPA), but has been
implicated in male reproductive dysfunction—including diminished sperm number and …