Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions
occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic …

The mammalian target of rapamycin complex 1 (mTORC1) inhibitor rapamycin and its
analogs are being increasingly used in solid-organ transplantation. A commonly reported …

In mammals, a testis-specific isoform of the protein kinase LKB1 is required for
spermiogenesis, but its exact function and specificity are not known. Human LKB1 rescues …

ABSTRACT LKB1/PAR-4 is essential for the earliest polarization steps in Caenorhabditis
elegans embryos and Drosophila oocytes. Although LKB1 (also known as STK11) is …

Formaldehyde (FA), a ubiquitous environmental pollutant, has long been suspected of
causing adverse male reproductive effects. However, the molecular and cellular …

Mammalian male fertility is maintained throughout life by a population of self-renewing
mitotic germ cells known as spermatogonial stem cells (SSCs). Much of our current …

Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to
about 30% of total sterility cases. However, there is little progress in treatments due to the …

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from
mutations in the dystrophin gene. The mdx/utrn−/− mouse, lacking in both dystrophin and its …

Adenosine monophosphate‐activated protein kinase (AMPK) plays a key role in cellular
energy homeostasis and cell proliferation. MicroRNAs (miRNAs) function as …

Abstract Serine/threonine kinase 11 (STK11) is a protein kinase that is encoded by Stk11
gene located on chromosome 19 and 10 in humans and mouse respectively. It acts as a …