The estrogenic chemical 4-nonylphenol (NP) is known to impair testicular devolopment and
spermatogenesis in rodents. The objective of this study was to explore the effects of NP on …

The mechanistic target of rapamycin (mTOR)(TOR1/TOR2 in yeast) was originally identified
in budding yeast through a genetic screen in 1991, 1, 2 and it is the target of a small …

The mechanistic target of rapamycin (mTOR) signaling is an evolutionally conserved
pathway that impacts many major cellular processes. This pathway integrates environmental …

Objective To investigate the role of Rictor/mTORC2 in the formation of blood testis barrier
(BTB), testicular development, and spermatogenesis. Methods Amh Cre positive mice …

Intestinal epithelium, the innermost cell layer of the intestine is capable of taking up nutrients
and fluid, and forming an otherwise impermeable layer. In order to do this, intestinal …

Cancer of the uterus is a common malignancy in women with no adequate treatments for
tumors that have progressed beyond the uterus. The serine-threonine kinase LKB1 has …

Numerous and extensive reviews have been written about basic morphology of the
mammalian Sertoli cell [1À9]. The purpose of this chapter is not to repeat all that has been …

Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis,
and they provide the foundation for spermatogenesis and life-long fertility. Currently, the …

Despite its immune privileged status, the testis is prone to inflammatory infertility. However,
sterile inflammation of the testis (autoimmune orchitis) is neglected as a cause of male factor …

Sessile benthic marine mollusks of the intertidal zone, such as the Pacific oyster Crassostrea
gigas, are exposed to large changes in environmental conditions every day. Over the tidal …