The role of macrophages in the pathogenesis of SARS-CoV-2-associated acute respiratory distress syndrome

A Kosyreva, D Dzhalilova, A Lokhonina… - Frontiers in …, 2021 - frontiersin.org
Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

The lung macrophage in SARS-CoV-2 infection: a friend or a foe?

Z Abassi, Y Knaney, T Karram, SN Heyman - Frontiers in Immunology, 2020 - frontiersin.org
Respiratory, circulatory, and renal failure are among the gravest features of COVID-19 and
are associated with a very high mortality rate. A common denominator of all affected organs …

Immunosenescence: a critical factor associated with organ injury after sepsis

X Lu, YM Yang, YQ Lu - Frontiers in Immunology, 2022 - frontiersin.org
Progressive immune dysfunction associated with aging is known as immunosenescence.
The age-related deterioration of immune function is accompanied by chronic inflammation …

Tracking the time course of pathological patterns of lung injury in severe COVID-19

T Mauad, AN Duarte-Neto, LFF da Silva… - Respiratory …, 2021 - Springer
Background Pulmonary involvement in COVID-19 is characterized pathologically by diffuse
alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory …

Diesel exhaust exposure in mice induces pulmonary fibrosis by TGF-β/Smad3 signaling pathway

N Singh, N Arora - Science of The Total Environment, 2022 - Elsevier
Background Epidemiological studies suggest increased risk of lung cancer associated with
diesel exhaust (DE) exposure. However, DE-induced lung fibrosis may lead to cancer and …

The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to …

LC Costa-Beber, FTCR Guma - Inflammation Research, 2022 - Springer
Introduction Cardiovascular diseases (CVD) have been associated with high exposure to
fine particulate air pollutants (PM2. 5). Alveolar macrophages are the first defense against …

[HTML][HTML] HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution

LC Costa-Beber, TG Heck, PBG Fiorin… - Cell Stress and …, 2021 - Elsevier
Physical exercise has acute and chronic effects on inflammatory balance, metabolic
regulation, and redox status. Exercise-induced adaptations are mediated by enhanced 70 …

Dimethyl fumarate attenuates lung inflammation and oxidative stress induced by chronic exposure to diesel exhaust particles in mice

I Cattani-Cavalieri, H da Maia Valença… - International journal of …, 2020 - mdpi.com
Air pollution is mainly caused by burning of fossil fuels, such as diesel, and is associated
with increased morbidity and mortality due to adverse health effects induced by inflammation …

Aerobic exercise ameliorates particulate matter-induced lung injury in aging rats

F Qin, S Cui, Y Dong, M Xu, Z Wang, C Qu… - Environmental Pollution, 2021 - Elsevier
Abstract Particulate matter 2.5 (PM 2.5) is an inflammatory-inducing factor that is considered
to be related to many adverse respiratory problems, especially in the elderly. This study …

Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema

JH Chang, YL Lee, V Laiman, CL Han, YT Jheng… - Chemico-Biological …, 2022 - Elsevier
Air pollution has been linked to emphysema in chronic obstruction pulmonary disease
(COPD). However, the underlying mechanisms in the development of emphysema due to air …