Background Immune system dysfunction is considered to play an aetiological role in
schizophrenia spectrum disorders, with substantial alterations in the concentrations of …

Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

1. Per-and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic
organic chemicals that are chemically stable, resistant to degradation, and persistent in …

Reduced gut-microbial diversity (“gut dysbiosis”) has been associated with an anhedonic/
amotivational syndrome (“sickness behavior”) that manifests across severe mental disorders …

Schizophrenia is a debilitating illness with a lifetime prevalence estimate of 0.6% and
consists of symptoms from the positive, negative, and cognitive domains. Social support …

Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin regulating synaptic plasticity,
neuronal excitability, and nociception. It seems to be one of the key molecules in interactions …

Introduction: Most medical diagnoses present somewhat differently in men and women,
more so at specific periods of life. Treatment effects may also differ. This is true for …

The term “immune-mediated inflammatory diseases (IMIDs)” refers to several inflammatory
pathologies of multifactorial etiology and involving either simultaneously or sequentially …