Molecular mechanism of sarcopenia and cachexia: recent research advances

K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2017 - Springer
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …

Exercise assessments and trainings of pulmonary rehabilitation in COPD: a literature review

Y Zeng, F Jiang, Y Chen, P Chen… - International journal of …, 2018 - Taylor & Francis
Skeletal muscle dysfunction leads to reduction in activity in patients with COPD. As an
essential part of the management of COPD, pulmonary rehabilitation (PR) alleviates …

A systematic review of diagnostic biomarkers of COPD exacerbation

YWR Chen, JM Leung, DD Sin - PloS one, 2016 - journals.plos.org
The aims of this systematic review were to determine which blood-based molecules have
been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease …

Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence

N Takasaka, J Araya, H Hara, S Ito… - The Journal of …, 2014 - journals.aai.org
Cigarette smoke (CS)–induced cellular senescence has been implicated in the
pathogenesis of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase …

The mechanisms of cachexia underlying muscle dysfunction in COPD

AHV Remels, HR Gosker… - Journal of applied …, 2013 - journals.physiology.org
Pulmonary cachexia is a prevalent, debilitating, and well-recognized feature of COPD
associated with increased mortality and loss of peripheral and respiratory muscle function …

Nutrition and respiratory health—feature review

BS Berthon, LG Wood - Nutrients, 2015 - mdpi.com
Diet and nutrition may be important modifiable risk factors for the development, progression
and management of obstructive lung diseases such as asthma and chronic obstructive …

Undernutrition in patients with COPD and its treatment

M Itoh, T Tsuji, K Nemoto, H Nakamura, K Aoshiba - Nutrients, 2013 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the
lung and whole body caused mainly by tobacco smoking. Patients with advanced COPD are …

Obesity, adipokines, and lung disease

A Sood - Journal of applied physiology, 2010 - journals.physiology.org
This review summarizes the state of the current literature relating to the associations of lung
disease on obesity and adipokines (proteins produced by adipose tissue) in humans …

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease

RCJ Langen, HR Gosker, AHV Remels… - The international journal …, 2013 - Elsevier
Skeletal muscle wasting contributes to impaired exercise capacity, reduced health-related
quality of life and is an independent determinant of mortality in chronic obstructive …

Association between tumor necrosis factor-α and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Y Yao, J Zhou, X Diao, S Wang - Therapeutic advances in …, 2019 - journals.sagepub.com
Background: Patients diagnosed with chronic obstructive pulmonary disease (COPD) have
increased risks for a series of physical and mental illnesses. Tumor necrosis factor-α (TNF-α) …