Background: R. Schofield (1978) proposed a hypothesis of hematopoietic stem cells (HSCs)
niche (specialized cell microenvironment). An existence of osteoblastic and vascular niches …

Hierarchical organized tissue structures, with stem cell driven cell differentiation, are critical
to the homeostatic maintenance of most tissues, and this underlying cellular architecture is …

Background Leukemias are malignant proliferative disorders of the blood forming system.
Sequencing studies demonstrate that the leukemic cell population consists of multiple …

Abstract Purpose of Review To maintain and repair adult tissues, a balance must be
maintained between stem cell proliferation and generation of differentiated offspring. This …

A large body of literature has emerged supporting the importance of cancer stem cells
(CSCs) in the pathogenesis of head and neck cancers. CSCs are a subpopulation of cells …

There is evidence that cancer develops when cells acquire a sequence of mutations that
alter normal cell characteristics. This sequence determines a hierarchy among the cells …

Tumor emergence and progression is a complex phenomenon that assumes special
molecular and cellular interactions. The hierarchical structuring and communication via …

Background Acute myelogenous leukemia (AML) progresses uniquely in each patient.
However, patients are typically treated with the same types of chemotherapy, despite …

Akute Leukämien bilden eine heterogene Gruppe schwerwiegender neoplastischer
Erkrankungen des blutbildenden Systems. Die in der vorliegenden Arbeit entwickelten und …

Cancer stem-like cells (CSCs) are a topic of increasing importance in cancer research, but
are difficult to study due to their rarity and ability to rapidly divide to produce non-self-cells …