Pathophysiology and treatment of cerebral edema in traumatic brain injury

RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury

A Drieu, A Lanquetin, P Prunotto… - Journal of Cerebral …, 2022 - journals.sagepub.com
Despite an apparently silent imaging, some patients with mild traumatic brain injury (TBI)
experience cognitive dysfunctions, which may persist chronically. Brain changes …

High-sensitivity C-reactive protein is a prognostic biomarker of six-month disability after traumatic brain injury: results from the TRACK-TBI study

LB Xu, JK Yue, F Korley, AM Puccio, EL Yuh… - Journal of …, 2021 - liebertpub.com
Systemic inflammation impacts outcome after traumatic brain injury (TBI), but most TBI
biomarker studies have focused on brain-specific proteins. C-reactive protein (CRP) is a …

Heart-type fatty acid-binding protein: an overlooked cardiac biomarker

H Goel, J Melot, MD Krinock, A Kumar… - Annals of …, 2020 - Taylor & Francis
Cardiac troponins (cTn) are currently the standard of care for the diagnosis of acute coronary
syndromes (ACS) in patients presenting to the emergency department (ED) with chest pain …

Colony stimulating factors in the nervous system

V Chitu, F Biundo, ER Stanley - Seminars in immunology, 2021 - Elsevier
Although traditionally seen as regulators of hematopoiesis, colony-stimulating factors (CSFs)
have emerged as important players in the nervous system, both in health and disease. This …

Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism

CN Bodnar, JM Morganti… - Neural regeneration …, 2018 - journals.lww.com
A substantial number of individuals have long-lasting adverse effects from a traumatic brain
injury (TBI). Depression is one of these long-term complications that influences many …

Glial fibrillary acidic protein (GFAP) outperforms S100 calcium-binding protein B (S100B) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as predictor for positive …

MY Mahan, M Thorpe, A Ahmadi, T Abdallah… - World neurosurgery, 2019 - Elsevier
Objective Traumatic brain injuries (TBIs) are largely underdiagnosed and may have
persistent refractory consequences. Current assessments for acute TBI are limited to …

Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury

D Tweedie, HK Karnati, R Mullins, CG Pick, BJ Hoffer… - Elife, 2020 - elifesciences.org
Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-
related neurological dysfunction. A lack of biomarkers of TBI has impeded medication …

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

DK Wright, RD Brady, A Kamnaksh, J Trezise, M Sun… - Scientific reports, 2019 - nature.com
A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but
repeated mTBI (RmTBI) is associated with cumulative and chronic neurological …