Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

The epidemic of overweight and obesity is a major problem because of the plethora of
health and economic issues that it induces. Key among these is the sharply increasing …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

Cell–cell communication within any given tissue is an important aspect of correct organ
function. The islets of Langerhans forming the endocrine pancreas are composed of α‐, β …

Evidence suggests associations between COVID-19 patients or vaccines and
glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein …

Human islets of Langerhans are complex micro-organs responsible for maintaining glucose
homeostasis. Islets contain five different endocrine cell types, which react to changes in …

The appropriate regulation of intracellular calcium is a requirement for proper cell function
and survival. This review focuses on the effects of proinflammatory cytokines on calcium …

Aims/hypothesis Pancreatic islet microendothelium exhibits unique features in
interdependent relationship with beta cells. Gastrointestinal products of the ghrelin gene …

Milk, the secretory product of the lactation genome, promotes growth of the newborn
mammal. Milk delivers insulinotropic amino acids, thus maintains a molecular crosstalk with …