Advances in the diagnosis and treatment of fungal infections of the CNS

S Schwartz, DP Kontoyiannis, T Harrison… - The Lancet …, 2018 - thelancet.com
Fungal infections of the CNS are challenging to treat and their optimal management requires
knowledge of their epidemiology, host characteristics, diagnostic criteria, and therapeutic …

Immunology of cryptococcal infections: developing a rational approach to patient therapy

W Elsegeiny, KA Marr, PR Williamson - Frontiers in immunology, 2018 - frontiersin.org
Cryptococcal meningoencephalitis is responsible for upwards of 15% of HIV-related deaths
worldwide and is currently the most common cause of non-viral meningitis in the US …

A multicenter, longitudinal cohort study of cryptococcosis in human immunodeficiency virus–negative people in the United States

KA Marr, Y Sun, A Spec, N Lu… - Clinical Infectious …, 2020 - academic.oup.com
Background Cryptococcosis is increasingly recognized in people without human
immunodeficiency virus (HIV). Methods A multicenter, prospective cohort study was …

CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis

LM Neal, E Xing, J Xu, JL Kolbe, JJ Osterholzer… - MBio, 2017 - Am Soc Microbiol
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …

[HTML][HTML] The war on cryptococcosis: a review of the antifungal arsenal

A Mourad, JR Perfect - Memórias do Instituto Oswaldo Cruz, 2018 - SciELO Brasil
Cryptococcal meningitis is the most common central nervous system infection in the world
today. It occurs primarily, but not exclusively, in immunocompromised individuals and …

Outcomes in previously healthy cryptococcal meningoencephalitis patients treated with pulse taper corticosteroids for post-infectious inflammatory syndrome

S Anjum, O Dean, P Kosa, MT Magone… - Clinical Infectious …, 2021 - academic.oup.com
Background Cryptococcal meningoencephalitis (CM) is a major cause of mortality in
immunosuppressed patients and previously healthy individuals. In the latter, a post …

Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome

K Ssebambulidde, SH Anjum, JC Hargarten… - Frontiers in …, 2022 - frontiersin.org
Cryptococcal meningoencephalitis (CM) continues to cause major morbidity and mortality in
a range of patients such as those immunosuppressed from HIV and with biologic …

Cryptococcal meningitis in young, immunocompetent patients: a single-center retrospective case series and review of the literature

M Stack, J Hiles, E Valinetz, SK Gupta… - Open Forum …, 2023 - academic.oup.com
Background Cryptococcal meningitis is an uncommon but serious infection with high
mortality and morbidity. Classically described in immunocompromised patients, including …

Cryptococcal immune reconstitution inflammatory syndrome: from clinical studies to animal experiments

ZW Shi, Y Chen, KM Ogoke, AB Strickland, M Shi - Microorganisms, 2022 - mdpi.com
Cryptococcus neoformans is an encapsulated pathogenic fungus that initially infects the
lung but can migrate to the central nervous system (CNS), resulting in meningoencephalitis …

Clinical aspects of immune damage in cryptococcosis

S Anjum, PR Williamson - Current fungal infection reports, 2019 - Springer
Abstract Purpose of Review To perform an extensive review of recent literature and provide
an update on the current epidemiology, clinical features, and management of cryptococcal …