Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH)
during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) …

Summary Background Obstructive Sleep Apnea (OSA) has been recognized as a major
health concern worldwide, given its increasing prevalence, difficulties in diagnosis and …

Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The
mechanisms that become dysregulated after periods of exposure to IH are unclear …

Background The identification of critically ill COVID-19 patients at risk of fatal outcomes
remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers …

Circulating cell-free microRNAs (miRNAs) represent a major reservoir for biomarker
discovery. Unfortunately, their implementation in clinical practice is limited due to a profound …

Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and
set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the …

Obstructive sleep apnoea is a substantial clinical and public health problem because it
contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and …

Over the past decades, sleep medicine has evolved as a novel discipline in health care. The
development of relevant medical specialties has invariably been preceded by major …

Sleep-disordered breathing (SDB), including obstructive and central sleep apnea,
significantly exacerbates heart failure (HF) through adverse cardiovascular mechanisms …

Background Patients with heart failure with reduced ejection fraction (HFrEF) and central
sleep apnea (CSA) are at a very high risk of fatal outcomes. Objective To test whether the …