[HTML][HTML] Carotenoids and their health benefits as derived via their interactions with gut microbiota

A Eroglu, IS Al'Abri, RE Kopec, N Crook, T Bohn - Advances in Nutrition, 2023 - Elsevier
Carotenoids have been related to a number of health benefits. Their dietary intake and
circulating levels have been associated with a reduced incidence of obesity, diabetes …

[HTML][HTML] Phytochemical composition and health benefits of figs (fresh and dried): a review of literature from 2000 to 2022

AK Sandhu, M Islam, I Edirisinghe, B Burton-Freeman - Nutrients, 2023 - mdpi.com
With their rich history dating back 6000 years, figs are one of the oldest known plants to
mankind and are a classical fruit in the Mediterranean diet. They possess a diverse array of …

iPADD: a computational tool for predicting potential antidiabetic drugs using machine learning algorithms

XW Liu, TY Shi, D Gao, CY Ma, H Lin… - Journal of Chemical …, 2023 - ACS Publications
Diabetes mellitus is a chronic metabolic disease, which causes an imbalance in blood
glucose homeostasis and further leads to severe complications. With the increasing …

[HTML][HTML] New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists

N Scarano, F Di Palma, N Origlia, F Musumeci… - Pharmaceutics, 2023 - mdpi.com
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in
the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits …

[HTML][HTML] Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions

R Baker, R Hontecillas, N Tubau-Juni… - npj Systems Biology …, 2022 - nature.com
We built a computational model of complex mechanisms at the intersection of immunity and
metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled …

Treating Autoimmune Diseases With LANCL2 Therapeutics: A Novel Immunoregulatory Mechanism for Patients With Ulcerative Colitis and Crohn's Disease

N Tubau-Juni, R Hontecillas, AJ Leber… - Inflammatory Bowel …, 2024 - academic.oup.com
Lanthionine synthetase C-like 2 (LANCL2) therapeutics have gained increasing recognition
as a novel treatment modality for a wide range of autoimmune diseases. Genetic ablation of …

[HTML][HTML] Biosensors for phytohormone abscisic acid and its role in humans: A review

J Narang, H Mohan - Sensors International, 2023 - Elsevier
ABA (abscisic acid) is a phytohormone that is important in regulating stress and various
pathological conditions in humans. ABA can be ingested exogenously or endogenously …

[HTML][HTML] First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis

N Tubau-Juni, R Hontecillas, A Leber… - Scientific Reports, 2021 - nature.com
Psoriasis (PsO) is a complex immune-mediated disease that afflicts 100 million people.
Omilancor is a locally-acting, small molecule that selectively activates the Lanthionine …

[HTML][HTML] Abscisic acid improves insulin action on glycemia in insulin-deficient mouse models of type 1 diabetes

M Magnone, S Spinelli, G Begani, L Guida, L Sturla… - Metabolites, 2022 - mdpi.com
Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia
regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism …

[HTML][HTML] The ABA/LANCL Hormone/Receptor System in the Control of Glycemia, of Cardiomyocyte Energy Metabolism, and in Neuroprotection: A New Ally in the …

S Spinelli, M Magnone, L Guida, L Sturla… - International Journal of …, 2023 - mdpi.com
Abscisic acid (ABA), long known as a plant stress hormone, is present and functionally
active in organisms other than those pertaining to the land plant kingdom, including …