Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of α-motor
neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

Different forms of physical activity—endurance, resistance or dynamic power—stimulate
cytokine release from various tissues to the bloodstream. Receptors for exercise-induced …

Sarcopenia and nonalcoholic fatty liver disease (NAFLD) are common health problems
related to aging. Despite the differences in their diagnostic methods, several cross-sectional …

The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal
muscle mass, which have been reported to primarily signal via the ActRIIB receptor on …

Purpose Regular resistance exercise training and a balanced diet may counteract the age-
related muscular decline on a molecular level. The aim of this study was to investigate the …

As the cirrhosis progresses, development of complication like ascites, hepatic
encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma …

A major issue in clinical endocrinology today is how to use hormones to achieve the health
benefits that they clearly can provide but avoid the negative side effects, that is, how to …

Cancer cachexia is a multifactorial syndrome characterized by an ongoing loss of skeletal
muscle mass, which negatively affects quality of life and portends a poor prognosis …

Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a
deleterious consequence of numerous complications associated with deteriorated renal …