Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell
activation pathways involved in physiological immune responses against specific antigens …

Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

Recent studies have suggested that the initiation and progression of hepatocellular
carcinoma (HCC) are closely associated with lipopolysaccharide (LPS) of intestinal bacteria …

The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However,
its potential role in lymphomagenesis remains unclear. In this study, we identified an …

Abstract Background Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer
progression and immune cell modulation. In this study, it was aimed to evaluate the roles of …

Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1 or CD279)
have noticeably improved the treatment landscape of advanced cancer patients. Nivolumab …

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and it
exhibits resistance to common breast cancer therapies. Immune checkpoint inhibitors (ICIs) …

Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …

Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted
transcription factor involved in multiple cellular functions. Its role in modifying anti-tumor …