Mitochondria are subcellular organelles involved in essential cellular functions, including
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated
biological effects include the regulation of circadian rhythms, which is important for optimal …

Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing
incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been …

The kidney is a mitochondria-rich organ, and kidney diseases are recognized as
mitochondria-related pathologies. Intact mitochondrial DNA (mtDNA) maintains normal …

Exposure to any number of stressors during the first 1000 days from conception to age 2
years is important in shaping an individual's life trajectory of health and disease. Despite the …

The development of novel therapeutics for the effective management of Parkinson's disease
(PD) is undertaken seriously by the scientific community as the burden of PD continues to …

The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the
leading cause of cognitive impairment and dementia in older individuals throughout the …

Abstract S‐adenosyl‐L‐methionine (SAM) is a coenzyme and the most commonly used
methyl‐group donor for the modification of metabolites, DNA, RNA and proteins. SAM …